Update on chronic immune thrombocytopenic purpura (ITP)

Update on chronic immune thrombocytopenic purpura (ITP)

Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...

An "Incremental" mathematical model for Immune Thrombocytopenic Purpura (ITP)

K e y w o r d s M a t h e m a t i c a l modeling, Biomathematics, Medical applications, Immune thrombocytopenic purpura (ITP). 1. I N T R O D U C T I O N The integr i ty of blood vessels is t aken in charge by platelets, which are a fract ion of the blood itself. Thei r n u m b e r usual ly ranges between 150 400 • 103#1-1. W h e n their level is less t han the lowest one, we speak abou t throm...

Autoimmune thrombocytopenic purpura ("ITP" type) with chronic lymphocytic leukemia.

[Update on thrombotic thrombocytopenic purpura].

PURPOSE Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder and early treatment is vital. Here, we review the recent advances in the understanding of the pathophysiology of TTP and its treatment. CURRENT KNOWLEDGE AND KEY POINTS Recent advances have shown that TTP is caused by deficiency of the (ADAMTS-13) metalloprotease that cleaves von Willebrand factor multimers. Acqu...

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response.

Derangement of cellular immunity is central in the pathophysiology of adult autoimmune/idiopathic thrombocytopenic purpura (ITP). Herein we investigated cytokine gene expression in peripheral blood mononuclear cells (PBMCs) of adult chronic ITP patients and attempted to correlate cytokine polarization with the degree of thrombocytopenia. We used semiquantitative reverse-transcriptase-polymerase...